New AVNRT Research Proposal
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Dear PACES friends, please see details on a new PACES approved research study.
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Clinical Research Protocol: Randomized Clinical Trial for Treatment of Atrioventricular Nodal Reentry Tachycardia (AVNRT): Low Voltage and Wave Front Collision Mapping vs. Anatomic/Electrogram Approach to Slow AV Nodal Pathway Ablation
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We are inviting interested Electrophysiology Investigators to participate in a prospective randomized clinical trial comparing the effectiveness and safety of two techniques for modification of slow AV nodal pathway conduction underlying AVNRT: 1) Ablation Technique 1 - low voltage and wave front collision mapping vs. 2) Ablation Technique 2 - anatomical/electrogram approach.
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Hypotheses: The effectiveness and safety of modifying slow AV nodal pathway conduction underlying AVNRT can be improved using low voltage and wave front collision mapping (Ablation Technique 1) compared with anatomical/electrogram approach (Ablation Technique 2).
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Primary End Point: The number of tissue ablations necessary to achieve successful modification of slow AV nodal pathway conduction. Patients will be stratified into either a cryoablation and RF group for analysis, depending on the energy source used during the ablation procedure.
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Secondary End Points: 1) The length of time needed to modify slow AV nodal pathway conduction. The time interval between starting the actual ablation part of the procedure for AVNRT and when the primary end point is achieved, slow pathway modification.
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2) Recurrence rate of AVNRT.
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